科学研究情况简介 |
【近5年来主要研究课题】 近年来主要围绕新型基因和药物递送系统构建及其在花粉症、肿瘤等免疫治疗方面的应用开展一系列基础研究；同时，也开发一系列基于胶原、透明质酸的医用水凝胶/水胶体材料，并开展其在伤口修复、瘢痕去除以及医美整形等方面的应用研究。 【近5年来主持项目】 [1] 噬菌体展示肽功能化糖原精准递送CpG ODN逆转Th1/Th2免疫应答失衡治疗花粉症的研究（21907041），国家自然科学基金 [2] 氮化硼纳米球提高CpG ODNs的免疫刺激活性联合阿霉素协同抗肿瘤的研究（BK20170202），江苏省自然科学基金 [3] 智能型CpG ODN/阿霉素纳米载药体系的构建及其靶向抗肿瘤研究，教育部“留学回国人员科研启动基金”
[4] 整形用透明质酸水凝胶的开发，企业项目
[5] 创可贴和造口袋底盘用水胶体研制，企业项目
【近5年来代表性论文】（*为通讯作者） [1] H. Zhang, W. Chen, K. Gong, J. Chen, Nanoscale Zeolitic Imidazolate Framework-8 as Efficient Vehicles for Enhanced Delivery of CpG Oligodeoxynucleotides, ACS Applied Materials & Interfaces, 2017 (9) 31519-31525. [2] H. Zhang, D. Huang, C. Yuan, T. Yan, S. Feng, H. Nakanishi, X.-D. Gao, Genetically engineered yeast spores as chitosan microspheres for intracellular delivery of immunostimulatory CpG oligodeoxynucleotides, Journal of Controlled Release, 2017 (259) e50. [3] H. Zhang, T. Cheng, L. Lai, S. Deng, R. Yu, L. Qiu, J. Zhou, G. Lu, C. Zhi, J. Chen, BN nanospheres functionalized with mesoporous silica for enhancing CpG oligodeoxynucleotide-mediated cancer immunotherapy, Nanoscale 10 (2018) 14516-14524. [4] Zhang, H.; Ding, A.; Ye, B.; Wang, Z.; Zhang, J.; Qiu, L.; Chen, J. Carbon Nitride Nanosheets for Imaging Traceable CpG Oligodeoxynucleotide Delivery. ACS Applied Nano Materials 2021, 4 (8), 8546-8555. [5] H. Zhang, T. Yan, S. Feng, D. Huang, C. Zhi, X.-D. Gao, Mesoporous silica functionalized boron nitride nanospheres for enhancing the immunostimulatory and antitumor effects of CpG ODNs, Nanomedicine: Nanotechnology, Biology and Medicine 14 (2018) 1823-1824. [6] H. Zhang, L. Lai, Y. Wang, B. Ye, S. Deng, A. Ding, L. Teng, L. Qiu, J. Chen, Silk fibroin for CpG oligodeoxynucleotides delivery, ACS Biomaterials Science & Engineering 2019 (11), 6082-6088 [7] H. Zhang, X.-D. Gao, Nanodelivery systems for enhancing the immunostimulatory effect of CpG oligodeoxynucleotides, Materials Science and Engineering: C, 2017 (70) 935-946. [8] H. Zhang, T. Yan, S. Xu, S. Feng, D. Huang, M. Fujita, X.-D. Gao, Graphene oxide-chitosan nanocomposites for intracellular delivery of immunostimulatory CpG oligodeoxynucleotides, Materials Science and Engineering: C, 2017 (73) 144-151. [9] H. Zhang, M. Peng, T. Cheng, P. Zhao, L. Qiu, J. Zhou, G. Lu, J. Chen, Silver nanoparticles-doped collagen–alginate antimicrobial biocomposite as potential wound dressing, Journal of Materials Science 53 (2018) 14944-14952. [10] Qiu, L.; Xu, J.; Ahmed, K. S.; Zhu, M.; Zhang, Y.; Long, M.; Chen, W.; Fang, W.; H. Zhang*; Chen, J*. Stimuli-responsive, dual-function prodrug encapsulated in hyaluronic acid micelles to overcome doxorubicin resistance. Acta Biomaterialia 2022, 140, 686-699. [11 T. Cheng, J. Miao, D. Kai, H. Zhang*, Polyethylenimine-Mediated CpG Oligodeoxynucleotide Delivery Stimulates Bifurcated Cytokine Induction, ACS Biomaterials Science & Engineering, 2018 (4) 1013-1018. [12] S. Feng, H. Li, Y. Ren, C. Zhi, Y. Huang, F. Chen*, H. Zhang*, RBC membrane camouflaged boron nitride nanospheres for enhanced biocompatible performance, Colloids and Surfaces B: Biointerfaces 190 (2020) 110964. [13] S. Naz, M. Wang, Y. Han, B. Hu, L. Teng, J. Zhou*, H. Zhang*, J. Chen, Enzyme-responsive mesoporous silica nanoparticles for tumor cells and mitochondria multistage-targeted drug delivery, International Journal of Nanomedicine 14 (2019) 2533-2542. [14] S. Feng, H. Zhang*, C. Zhi, X.-D. Gao, H. Nakanishi*, pH-responsive charge-reversal polymer-functionalized boron nitride nanospheres for intracellular doxorubicin delivery, International Journal of Nanomedicine, 2018 (13) 641-652. [15] T. Yan, H. Zhang*, D. Huang, S. Feng, M. Fujita, X.-D. Gao*, Chitosan-Functionalized Graphene Oxide as a Potential Immunoadjuvant, Nanomaterials, 2017 (7) 59. 【主5年来主要授权专利】 用于生产糖蛋白的动物细胞株及方法、糖蛋白及其用途. PCT/CN2018/084551 海藻酸钠/胶原/石墨相氮化碳纳米片光催化抗菌膜的制备. CN110169979A 一种高粘附性抗菌促愈合水凝胶及其制备方法. CN202110410154.8 一种具有靶向性的CpG核酸药物递送系统及其制备方法. CN202110584701.4 一种高粘附性抗菌促愈合水凝胶及其制备方法. PCT/CN2021/121632 一种可见光响应的光催化抗菌促愈合水凝胶及其制备方法. CN202011412136.5 【主要奖励】 2020 江苏省第十二批科技镇长团省级优秀团员 2018-2019, 2020-2021 太阳集团娱乐至善青年学者 2019 太阳集团娱乐教学成果奖二等奖 2020 太阳集团娱乐本科优秀毕业论文指导教师 2019 第五届“互联网+”大学生创新创业大赛获得省级三等奖 2015 药明康德奖教金 |
