科学研究情况简介 |
【近5年来主要研究课题】 1.含糖高分子材料的设计及生物医学应用 2.抗氧化纳米材料的构建及临床应用转化 【近5年来主持项目】 1.硫酸化糖纳米粒子选择性诱导肿瘤凋亡作用及机制研究(国家自然科学基金-面上) 2.多功能糖纳米粒子的制备及抗肿瘤应用(中央高校基本科研项目) 3.硫酸软骨素寡糖的化学-酶法合成、构效关系及应用研究(中央高校基本科研项目) 【近5年来代表性论文】 1.Caiyan Zhao, Jingxiao Chen, Ruibo Zhong, Dean Shuailin Chen, Jinjun Shi, Jibin Song. Oxidative species-selective materials for diagnostic and therapeutic applications. Angew Chem Int Ed. 2020. 2.Haitao Wu, Manlin Su, Hui Jin, Xinyu Li, Puyu Wang, Jingxiao Chen, Jinghua Chen. Rutin-loaded silver nanoparticles with antithrombotic function. Front Bioeng Biotech. 2020,8: 598977. 3.Yaling Wu, Zheng Xu, Wenjing Sun, Yingyue Yang, Hui Jin, Lipeng Qiu, Jinghua Chen, Jingxiao Chen. Co-responsivesmart cyclodextrin-gated mesoporous silica nanoparticles with ligand-receptor engagement for anti-cancer treatment. Mater Sci & Eng C. 2019, 103: 109831. 4.Jing Wu, Jiayi Yuan, Baotong Ye, Yaling Wu, Zheng Xu, Jinghua Chen, Jingxiao Chen. Dual-responsive core crosslinking glycopolymer-drug conjugates nanoparticles for precise hepatocarcinoma therapy. Front Pharmacol. 2018, 9: 663. 5.Jiayi Yuan, Baotong Ye, Jing Wu, Ying Li, Jinghua Chen, Jingxiao Chen. Study on sulfated glycosylated Fe3O4@SiO2 nanoparticles inducing tumor cell apoptosis. Chem J Chine Univ-Chin. 2018, 39:2458-2467. 6.Baotong Ye, Zhi Cai, Jing Wu, Xin Lin, Jingxiao Chen, Jinghua Chen. Preparation of sulfonated galactose-based glycopolymers and interactions with lectins. Acta Polym Sin. 2018, 4: 490-498. 7.Jingxiao Chen, Jing Yuan, Yaling Wu, Ping Wang, Peng Zhao, Guozhong Lv, Jinghua Chen. Fabrication of tough poly(ethylene glycol)/collagen double network hydrogels for tissue engineering. J Biomed Mater Res Part A, 2018, 106A: 192-200. 8.Jingxiao Chen, Lujuan Cao, Yu Shi, Ping Wang, Jinghua Chen. In situ supramolecular hydrogel based on hyaluronic acid and dextran derivatives as cell scaffold. J Biomed Mater Res Part A 2016, 104A: 2263–2270. 9.Jingxiao Chen, Yu Shi, Yirang Zhang, Liping Teng, Jinghua Chen. One-pot construction of boronate ester based pH-responsive micellefor combined cancer therapy. Colloid Surface B. 2016, 143: 285-292. 【近5年主要授权专利】 1.一种抑菌并可促伤口修复壳聚糖水凝胶敷料的制备方法. ZL201710705847.3 2.一种磷氮协效水溶性高分子阻燃剂的制备方法. ZL201710628989.4 【主要奖励】 1.教育部科技进步二等奖 2.江苏省“双创博士” 3.扬州市“绿杨金凤”人才 4.第十二届太阳集团娱乐“我最喜爱的老师” |