【近5年来主持项目】 [1] 重点研发计划子课题,2021YFC2103100。 [2] 国家自然科学基金青年项目,81503007。 [3] 中国博士后科学基金面上(一等资助)项目,2019M660166。 [4] 江苏省自然科学基金面上项目,BK20201344。 [5] 山东省博士后创新项目,202002039。 [6] 透明质酸冻干制剂的研发,企业项目。 [7] 延胡索乙素纳米微乳的研制,企业项目。 [8] 新型小分子化合物可开发性研究,企业项目。 【近5年来代表性论文】 多年来,围绕多糖生物载体材料合成、智能药物递送系统构建、细胞和动物作用评价等进行研究,以一作/通讯作者在专业期刊发表SCI论文20余篇,其中,一区SCI论文10篇,近5年累积引用约1000次,H指数16。主要代表作如下: [1] Enhanced Effect of pH-Sensitive Mixed Copolymer Micelles for Overcoming Multidrug Resistance of Doxorubicin. Biomaterials. 2014, 35(37): 9877-9887. [2] Self-assembled pH-responsive Hyaluronic Acid-g-poly (L-histidine) Copolymer Micelles for Targeted Intracellular Delivery of Doxorubicin. Acta Biomaterialia. 2014, 10 (5): 2024-2035. [3] cRGDyK modified pH responsive nanoparticles for specific intracellular delivery of doxorubicin. Acta Biomaterialia. 2016, 30: 285-298. [4] pH-Sensitive degradable polymeric micelles for bio-triggered targeted anti-tumor drug delivery, J Control Release. 2017, 259: e86-e87. [5] pH-triggered degradable polymeric micelles for targeted anti-tumor drug delivery. Mater Sci Eng C Mater Biol Appl. 2017, 78: 912-922. [6] Designing heparan sulfate-based biocompatible polymers and their application for intracellular stimuli-sensitive drug delivery. Mater Sci Eng C Mater Biol Appl. 2019, 94: 465-476. [7] Derma roller® microneedles-mediated transdermal delivery of doxorubicin and celecoxib co-loaded liposomes for enhancing the anticancer effect. Mater Sci Eng C Mater Biol Appl. 2019, 99:1448-1458. [8] Elucidation of cellular uptake and intracellular trafficking of heparosan polysaccharide-based micelles in various cancer cells. Int J Biol Macromol. 2019, 130:755-764. [9] Redox-responsive biocompatible nanocarriers based on novel heparosan polysaccharides for intracellular anticancer drug delivery. Asian J Pharm Sci. 2020, 15(1): 83-94. [10] A facile synthesis of uniform hollow MIL-125 titanium-based nanoplatform for endosomal esacpe and intracellular drug delivery. Chem Eng J, 2020, 396: 125246. [11] Overcoming multidrug resistance by intracellular drug release and inhibiting p-glycoprotein efflux in breast cancer. Biomed Pharmacother, 2021, 134: 111108. [12] Bacteria-mediated cancer therapies: opportunities and challenges. Biomater Sci. 2021, 9(17): 5732-5744. [13] Biological role of heparan sulfate in osteogenesis: A review. Carbohydr Polym. 2021, 272: 118490. [14] Carbon Nitride Nanosheets for Imaging Traceable CpG Oligodeoxynucleotide Delivery. ACS Appl Nano Mater, 2021, 4(8): 8546-8555. [15] Fabrication of pH/Reduction Sensitive Polyethylene Glycol-Based Micelles for Enhanced Intracellular Drug Release. Pharmaceutics. 2021, 13(9): 1464. [16] Stimuli-responsive, dual-function prodrug encapsulated in hyaluronic acid micelles to overcome doxorubicin resistance. Acta Biomater. 2021, 140:686-699. 【近5年主要授权专利】 [1] 一种肝素前体多糖聚合物及其制备方法和应用,201811562526.3. [2] 一种肝素衍生物-泊洛沙姆温敏型水凝胶及其制备方法,201810901872.3 [3] 一种注射用多功能复合型水凝胶及其制备方法,201810185988.1 [4] 一种塞来昔布微晶、负载塞来昔布微晶的温敏性凝胶及其制备方法,202110773477.3 【主要奖励】 全国挑战杯优秀指导教师 太阳集团娱乐“青年至善学者” 太阳集团娱乐教学成果特等奖 太阳集团娱乐优秀毕业论文指导教师 高等学校科学研究技术进步二等奖 中国商业联合会科技进步一等奖 中国轻工业联合会科技进步二等奖 |