科学研究情况简介 |
【近5年来主要研究课题】 有机合成方法学研究；杂环化合物的设计与合成；化学制药工艺开发 【近5年来主持项目】 1. BK20150129，江苏省自然科学基金-青年，主持 2. 江苏省双创博士《境外世界名校类》，主持人 3. JUSRP11546，太阳集团娱乐自主科研计划，主持人 另外，主持多项横向课题。 【近5年来代表性论文】 1. J. Yuan, R. Peng, D. Cheng*, L. H. Zou*, L. Yuan*, Chem. Asian J. 2021, 16, 342-347. Revealing minor pH changes of mitochondria by a highly sensitive molecular fluorescent probe. 2. K. Shi, H. Zhu, F. Ren, S. Liu, Y.-Y. Song, W. Li,* L.-H. Zou*, Eur. J. Org. Chem. 2021, 1003-1006. Copper-catalyzed [3+2+1] annulation of anthranils with phenylacetaldehydes: Synthesis of 8-acylquinolines. 3. S. Zhu, K. Shi, H. Zhu, Z.-K. Jia, X.-F. Xia, D. Wang, L.-H. Zou*, Org. Lett. 2020, 22, 1504-1509 (JCR一区). Copper-catalyzed annulation or homocoupling of sulfoxonium ylides: synthesis of 2,3-diaroylquinolines or α,α,β-tricarbonyl sulfoxonium ylides. 4. L.-H. Zou*, H. Zhu, S. Zhu, K. Shi, C. Yan, P.-G. Li, J. Org. Chem. 2019, 84, 12301-12313. Copper-catalyzed ring-opening/reconstruction of anthranils with oxo-compounds: synthesis of quinoline derivatives. 5. P.-G. Li, C. Yan, S. Zhu, S.-H. Liu, L.-H. Zou*, Org. Chem. Front. 2018, 5, 3464-3468 (JCR一区). Direct construction of benzimidazo[1,2-c]quinazolin-6-ones via metal-free oxidative C-C bond cleavage. 6. L.-H. Zou*, C. Zhao, P.-G. Li, Y. Wang, J. Li*, J. Org. Chem. 2017, 82, 12892-12898. Transition-metal-free C−S bond formation: synthesis of polysubstituted diaryl sulfides and α-thioarylcarbonyl compounds. 7. L.-H. Zou*, M. Fan, L. Wang*, C. Liu*, Chin. Chem. Lett. 2019, 31, 1911-1913 (JCR一区). Hetero diacylation of 1,1-diborylalkanes: practical synthesis of 1,3-diketones. 8. L.-H. Zou*, C. Yan, K. Shi, L. Su, S. Zhu, Z.-K. Jia, Q. Wang*, Eur. J. Org. Chem. 2019, 7725-7729. Copper-catalyzed C–C bond cleavage/double cyclization of α-ketoamides with o-phenylene diamines: synthesis of benzimidazo[1,2-c]quinazolin-6-ones. 9. P.-G. Li, H. Zhu, M. Fan, C. Yan, K. Shi, X.-W. Chi, L.-H. Zou*, Org. Biomol. Chem. 2019, 17, 5902-5907. Copper-catalyzed coupling of anthranils and α-keto acids: direct synthesis of α-ketoamides. 10. Y. Wang, S. Zhu, L.-H. Zou*, Eur. J. Org. Chem. 2019, 2179-2201. Recent advances in direct functionalization of quinones. 11. L.-H. Zou*, Y.-C. Li, P.-G. Li, J. Zhou, Z. Wu*, Eur. J. Org. Chem. 2018, 5639-5643. Solvent-controlled α-monobromination, α,α-dibromination or imidation of 1,3-diketones with N-bromosuccinimide. (VIP paper) 12. P.-G. Li*, Y. Yang, S. Zhu, H.-X. Li, L.-H. Zou*, Eur. J. Org. Chem. 2019, 73-76. Pd-catalyzed regioselective direct double C−H arylation of 6,7-benzindoles. (VIP paper) 13. P.-G. Li, Y.-C. Li, T. Zhu, L.-H. Zou*, Z. Wu*, Eur. J. Org. Chem. 2017, 6081-6084. Hydroxysulfonylation of quinones with aryl(alkyl)sulfonyl hydrazides for the synthesis of 1,4-dihydroxy-2-aryl(alkyl)sulfonylbenzenes. 14. Z. Wu*, Y.-C. Li, W.-Z. Ding, T. Zhu, S.-Z. Liu, X. Ren, L.-H. Zou*, Asian J. Org. Chem. 2016, 5, 625-628. Copper-catalyzed regioselective sulfenylation of indoles with arylsulfonyl chlorides. 【近5年主要授权专利】 1. Synthetic Method for Benzimidazo[1,2-C]quinazolin-6-ones，US 11,098,049B2（排名第一）。 2. 一种8-酰基喹啉衍生物的合成方法，ZL 202011448666.5（排名第一）。 3. 一种邻位醛基的α-酮酰胺类化合物的合成方法ZL 201910211907.5（排名第一）。 4. 一种喹啉衍生物的合成方法ZL 20191054366.9（排名第一）。 5. 一种α,α,β-三羰基硫叶立德化合物的合成方法ZL 201911250278.3（排名第一）。 6. 一种2,3-二酰基喹啉类化合物的合成方法ZL 202011506295.1（排名第一）。 |
